Translational readthrough induction of pathogenic nonsense mutations.

  title={Translational readthrough induction of pathogenic nonsense mutations.},
  author={Rich{\'a}rd Kellermayer},
  journal={European journal of medical genetics},
  volume={49 6},
The treatment of genetic disorders is one of the biggest challenges lying ahead of modern medicine. While major advancements have been made in gene therapy, it is still far from achieving clinical success. However, other potential methods for treating single gene related diseases have also emerged recently. One such approach is the suppression of pathogenic nonsense mutations through inducing translational readthrough of the in-frame premature stop mutation. Aminoglycosides were the first drugs… CONTINUE READING

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