Translational principles of deep brain stimulation

@article{Kringelbach2007TranslationalPO,
  title={Translational principles of deep brain stimulation},
  author={Morten L. Kringelbach and Ned Jenkinson and Sarah L. F. Owen and Tipu Z. Aziz},
  journal={Nature Reviews Neuroscience},
  year={2007},
  volume={8},
  pages={623-635}
}
Deep brain stimulation (DBS) has shown remarkable therapeutic benefits for patients with otherwise treatment-resistant movement and affective disorders. This technique is not only clinically useful, but it can also provide new insights into fundamental brain functions through direct manipulation of both local and distributed brain networks in many different species. In particular, DBS can be used in conjunction with non-invasive neuroimaging methods such as magnetoencephalography to map the… Expand
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Deep brain stimulation is clinically effective in improving motor function of essential tremor, Parkinson's disease and primary dystonia and in relieving obsessive-compulsive disorder. Expand
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The research done to date on the effects of DBS and TMS on motor, cognition and behaviour in Parkinson's disease (PD) with particular emphasis on neuroimaging is outlined. Expand
Deep brain stimulation and the role of astrocytes
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The potential role of reactive and neurogenic astrocytes (neural progenitors) in DBS will be discussed, and how high-frequency stimulation of these cells may lead to alleviation of the clinical symptoms is discussed. Expand
Disrupting neuronal transmission: mechanism of DBS?
TLDR
This review will examine the neurophysiological mechanism underling the action of DBS and propose the alternative interpretation: DBS dissociates inputs and outputs, resulting in disruption of abnormal signal transmission. Expand
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How detailed investigations of the highly coherent functional and structural brain networks in health and disease have the potential not only to increase the understanding of fundamental brain function but of how best to modulate the balance is reviewed. Expand
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The physiological mechanism of DBS is discussed and an alternative view is proposed: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site. Expand
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