Translational principles of deep brain stimulation

  title={Translational principles of deep brain stimulation},
  author={Morten L. Kringelbach and Ned Jenkinson and Sarah L. F. Owen and Tipu Z. Aziz},
  journal={Nature Reviews Neuroscience},
Deep brain stimulation (DBS) has shown remarkable therapeutic benefits for patients with otherwise treatment-resistant movement and affective disorders. This technique is not only clinically useful, but it can also provide new insights into fundamental brain functions through direct manipulation of both local and distributed brain networks in many different species. In particular, DBS can be used in conjunction with non-invasive neuroimaging methods such as magnetoencephalography to map the… 
Mechanism of Deep Brain Stimulation
  • S. ChikenA. Nambu
  • Medicine
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2016
This short review would like to introduce the recent work on the physiological mechanism of DBS and propose an alternative explanation: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.
Deep Brain Stimulation
Deep brain stimulation is clinically effective in improving motor function of essential tremor, Parkinson's disease and primary dystonia and in relieving obsessive-compulsive disorder.
Neuroethical principles of deep-brain stimulation.
Combining functional imaging with brain stimulation in Parkinson's disease
The research done to date on the effects of DBS and TMS on motor, cognition and behaviour in Parkinson's disease (PD) with particular emphasis on neuroimaging is outlined.
Deep brain stimulation and the role of astrocytes
The potential role of reactive and neurogenic astrocytes (neural progenitors) in DBS will be discussed, and how high-frequency stimulation of these cells may lead to alleviation of the clinical symptoms is discussed.
Disrupting neuronal transmission: mechanism of DBS?
This review will examine the neurophysiological mechanism underling the action of DBS and propose the alternative interpretation: DBS dissociates inputs and outputs, resulting in disruption of abnormal signal transmission.
Balancing the Brain: Resting State Networks and Deep Brain Stimulation
How detailed investigations of the highly coherent functional and structural brain networks in health and disease have the potential not only to increase the understanding of fundamental brain function but of how best to modulate the balance is reviewed.
Mechanism of DBS: Inhibition, Excitation, or Disruption?
The physiological mechanism of DBS is discussed and an alternative view is proposed: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.
Novel methods and circuits for field shaping in deep brainstimulation
Two approaches to achieve dynamic electric field control during deep brain stimulation are proposed, based on the use of current-steering multipolar electrodes and phased arrays in order to create an electromagnetic beam, which can be steered to a desired location.


Blood flow responses to deep brain stimulation of thalamus
The increased blood flow at terminal fields of thalamocortical projections suggests that DBS stimulates and does not inactivate projection neurons in VIM thalamus.
Mechanisms of deep brain stimulation: Excitation or inhibition
  • J. Vitek
  • Biology
    Movement disorders : official journal of the Movement Disorder Society
  • 2002
This hypothesis would explain the present experimental results, is consistent with excitability profiles of neuronal elements based on their biophysical properties, and fits with more recent models emphasizing the role of altered patterns of neuronal activity in the development of hypokinetic and hyperkinetic movement disorders.
Stimulation-induced inhibition of neuronal firing in human subthalamic nucleus
The present findings suggest that local HF stimulation inhibits many STN neurons, and the overall effects of DBS stimulation in STN are likely to be inhibition of intrinsic and synaptically mediated activity, and its replacement by regular high-frequency firing.
Obsessive-Compulsive Disorder: Development of Demand-Controlled Deep Brain Stimulation with Methods from Stochastic Phase Resetting
A first conceptualization is presented suggesting that the nucleus accumbens is a promising target for the standard, that is, permanent high-frequency, DBS in patients with severe and chronic obsessive-compulsive disorder (OCD).
Deep brain stimulation in dystonia
The optimal target for different dystonic disorders remains to be determined, although the globus pallidus internus has currently emerged as the most promising target for dystonia.
Deep brain stimulation for cluster headache
Globus pallidus deep brain stimulation for generalized dystonia: Clinical and PET investigation
Altering basal ganglia function with GPi DBS reverses the overactivity of certain motor cortical areas present in dystonia.
Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans
PET data in living parkinsonian humans do not provide evidence for an increased striatal dopamine concentration under effective STN‐DBS, and it is concluded that the modulation of dopaminergic activity does not seem to play a crucial role for the stimulation's mechanisms of action in parkinsonia humans.
Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition.
The hypothesis of stimulation-induced modulation of pathological network activity as a therapeutic mechanism of DBS is supported after apparently contradictory results showing suppression of activity in the stimulated nucleus, but increased inputs to projection nuclei.