Translational principles of deep brain stimulation

@article{Kringelbach2007TranslationalPO,
  title={Translational principles of deep brain stimulation},
  author={Morten L. Kringelbach and Ned Jenkinson and Sarah L. F. Owen and Tipu Z. Aziz},
  journal={Nature Reviews Neuroscience},
  year={2007},
  volume={8},
  pages={623-635}
}
Deep brain stimulation (DBS) has shown remarkable therapeutic benefits for patients with otherwise treatment-resistant movement and affective disorders. This technique is not only clinically useful, but it can also provide new insights into fundamental brain functions through direct manipulation of both local and distributed brain networks in many different species. In particular, DBS can be used in conjunction with non-invasive neuroimaging methods such as magnetoencephalography to map the… Expand
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A general scheme of selecting stimulation parameters in DBS is described and clinical and neurophysiological arguments for such a standardized algorithm are provided and noninvasive technical trouble shooting is described by using programming features of the commercially available neurostimulation devices. Expand
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TLDR
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The present findings suggest that local HF stimulation inhibits many STN neurons, and the overall effects of DBS stimulation in STN are likely to be inhibition of intrinsic and synaptically mediated activity, and its replacement by regular high-frequency firing. Expand
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A first conceptualization is presented suggesting that the nucleus accumbens is a promising target for the standard, that is, permanent high-frequency, DBS in patients with severe and chronic obsessive-compulsive disorder (OCD). Expand
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