Translational mini-review series on complement factor H: structural and functional correlations for factor H.

@article{Schmidt2008TranslationalMS,
  title={Translational mini-review series on complement factor H: structural and functional correlations for factor H.},
  author={Christoph Q. Andreas Schmidt and Andrew Herbert and Henry G. Hocking and Du{\vs}an Uhr{\'i}n and Paul N. Barlow},
  journal={Clinical and experimental immunology},
  year={2008},
  volume={151 1},
  pages={14-24}
}
The 155-kDa glycoprotein, complement factor H (CFH), is a regulator of complement activation that is abundant in human plasma. Three-dimensional structures of over half the 20 complement control protein (CCP) modules in CFH have been solved in the context of single-, double- and triple-module segments. Proven binding sites for C3b occupy the N and C termini of this elongated molecule and may be brought together by a bend in CFH mediated by its central CCP modules. The C-terminal CCP 20 is key… CONTINUE READING

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Binding of factor H to C-reactive protein occurs only when the latter has undergone non-physiologic denaturation

S Hakobyan, CL Harris, C van den Berg, MB Pepys, BP. Morgan
Mol Immunol • 2007

Mutation in factor H (Y402H) associated with age related macular degeneration (AMD) results in reduced binding activities

C Skerka, N Lauer, A Hatmann, S Heinan
Mol Immunol • 2007

Spontane - ous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains

MC Pickering, EG deJorge, R Martinez-Barricarte
J Exp Med • 2007

Binding of complement

TS Jokiranta, ZZ Cheng, H Seeberger
J Biol Chem • 2006
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