Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies.

@article{Dinman1994TranslationalMO,
  title={Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies.},
  author={Jonathan D. Dinman and Reed B Wickner},
  journal={Genetics},
  year={1994},
  volume={136 1},
  pages={75-86}
}
A special site on the (+) strand of the L-A dsRNA virus induces about 2% of ribosomes translating the gag open reading frame to execute a -1 frameshift and thus produce the viral gag-pol fusion protein. Using constructs in which a -1 ribosomal frameshift at this site was necessary for expression of lacZ we isolated chromosomal mutants in which the efficiency of frameshifting was increased. These mutants comprise eight genes, named mof (maintenance of frame). The mof1-1, mof2-1, mof4-1, mof5-1… CONTINUE READING
28 Citations
26 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Elimination of L - A dsRNA virus of yeast by expression of gag and gag - pol from an L - A cDNA clone

  • R. B. WICKNER
  • J . Virol .
  • 1993

Mutational analysis of the “ slippery - sequence ” component of a coronavirus ribosomal frameshifting signal

  • I. BRIERLEY, N. J. ROLLEY
  • J . Mol . Biol .
  • 1992

Structural and functional aspects of RNA pseudoknots

  • TEN DAM, K. PLEIJ
  • Biochemistry
  • 1992

Similar Papers

Loading similar papers…