Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities.

@article{Khaleghpour1999TranslationalHE,
  title={Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities.},
  author={Kianoush Khaleghpour and St{\'e}phane Pyronnet and Alexandre Gingras and Nahum Sonenberg},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 6},
  pages={4302-10}
}
Eukaryotic translation initiation factor 4E (eIF4E) is the mRNA 5' cap binding protein, which plays an important role in the control of translation. The activity of eIF4E is regulated by a family of repressor proteins, the 4E-binding proteins (4E-BPs), whose binding to eIF4E is determined by their phosphorylation state. When hyperphosphorylated, 4E-BPs do not bind to eIF4E. Phosphorylation of the 4E-BPs is effected by the phosphatidylinositol (PI) 3-kinase signal transduction pathway and is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Metabolite sensing and signaling in cell metabolism

Signal Transduction and Targeted Therapy • 2018

Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages.

Proceedings of the National Academy of Sciences of the United States of America • 2014
View 2 Excerpts

Similar Papers

Loading similar papers…