Translational fusion of chloroplast-expressed human papillomavirus type 16 L1 capsid protein enhances antigen accumulation in transplastomic tobacco

@article{Lenzi2008TranslationalFO,
  title={Translational fusion of chloroplast-expressed human papillomavirus type 16 L1 capsid protein enhances antigen accumulation in transplastomic tobacco},
  author={Paolo Lenzi and Nunzia Scotti and Fiammetta Alagna and Maria Lina Tornesello and Andrea Pompa and Alessandro Vitale and Angelo De Stradis and Luigi Monti and Stefania Grillo and Franco M. Buonaguro and Pal Maliga and Teodoro Cardi},
  journal={Transgenic Research},
  year={2008},
  volume={17},
  pages={1091-1102}
}
Human Papillomavirus (HPV) is the causal agent of cervical cancer, one of the most common causes of death for women. The major capsid L1 protein self-assembles in Virus Like Particles (VLPs), which are highly immunogenic and suitable for vaccine production. In this study, a plastid transformation approach was assessed in order to produce a plant-based HPV-16 L1 vaccine. Transplastomic plants were obtained after transformation with vectors carrying a chimeric gene encoding the L1 protein either… CONTINUE READING
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