Translational control by eIF2α in neurons: Beyond the stress response.

@article{Bellato2016TranslationalCB,
  title={Translational control by eIF2α in neurons: Beyond the stress response.},
  author={Hermano Martins Bellato and Glaucia Noeli Maroso Hajj},
  journal={Cytoskeleton},
  year={2016},
  volume={73 10},
  pages={551-565}
}
The translation of mRNAs is a tightly controlled process that responds to multiple signaling pathways. In neurons, this control is also exerted locally due to the differential necessity of proteins in axons and dendrites. The phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2α) is one of the mechanisms of translational control. The phosphorylation of eIF2α has classically been viewed as a stress response, halting translation initiation. However, in the nervous… CONTINUE READING