Translational challenges of animal models in Chagas disease drug development: a review

@inproceedings{Chatelain2015TranslationalCO,
  title={Translational challenges of animal models in Chagas disease drug development: a review},
  author={Eric Chatelain and Nandini Konar},
  booktitle={Drug design, development and therapy},
  year={2015}
}
Chagas disease, or American trypanosomiasis, caused by Trypanosoma cruzi parasite infection is endemic in Latin America and presents an increasing clinical challenge due to migrating populations. Despite being first identified over a century ago, only two drugs are available for its treatment, and recent outcomes from the first clinical trials in 40 years were lackluster. There is a critical need to develop new drugs to treat Chagas disease. This requires a better understanding of the… CONTINUE READING
14 Citations
123 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 123 references

Chagas disease

  • Rassi A, A Rassi, JA Marin-Neto
  • 2010
Highly Influential
4 Excerpts

Organisation

  • WHO. World Healt
  • Third WHO report on neglected tropical diseases…
  • 2015
1 Excerpt

Similar Papers

Loading similar papers…