Translational advances regarding hereditary breast cancer syndromes

  title={Translational advances regarding hereditary breast cancer syndromes},
  author={M. Gage and D. Wattendorf and L. Henry},
  journal={Journal of Surgical Oncology},
  • M. Gage, D. Wattendorf, L. Henry
  • Published 2012
  • Medicine
  • Journal of Surgical Oncology
  • Approximately 5–10% of breast cancers may be inheritable, up to 90% of which are due to mutations in BRCA1 and BRCA2. A substantial minority are caused by non‐BRCA mutations, such as TP53, PTEN, STK11, CHEK2, ATM, BRIP1, and PALB2 mutations. This review highlights translational research advances with regard to the development of probabilistic models for hereditary breast cancer syndromes, the identification of specific genetic mutations responsible for these syndromes, as well as their testing… CONTINUE READING
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