• DOI:10.1002/jso.21856
Corpus ID: 3406636

Translational advances regarding hereditary breast cancer syndromes

@article{Gage2012TranslationalAR,
  title={Translational advances regarding hereditary breast cancer syndromes},
  author={M. Gage and D. Wattendorf and L. Henry},
  journal={Journal of Surgical Oncology},
  year={2012},
  volume={105}
}

M. Gage, D. Wattendorf, L. Henry

Published 2012

Medicine

Journal of Surgical Oncology

Approximately 5–10% of breast cancers may be inheritable, up to 90% of which are due to mutations in BRCA1 and BRCA2. A substantial minority are caused by non‐BRCA mutations, such as TP53, PTEN, STK11, CHEK2, ATM, BRIP1, and PALB2 mutations. This review highlights translational research advances with regard to the development of probabilistic models for hereditary breast cancer syndromes, the identification of specific genetic mutations responsible for these syndromes, as well as their testing… CONTINUE READING

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