Translational advances regarding hereditary breast cancer syndromes

@article{Gage2012TranslationalAR,
  title={Translational advances regarding hereditary breast cancer syndromes},
  author={M. Gage and D. Wattendorf and L. Henry},
  journal={Journal of Surgical Oncology},
  year={2012},
  volume={105}
}
  • M. Gage, D. Wattendorf, L. Henry
  • Published 2012
  • Medicine
  • Journal of Surgical Oncology
  • Approximately 5–10% of breast cancers may be inheritable, up to 90% of which are due to mutations in BRCA1 and BRCA2. A substantial minority are caused by non‐BRCA mutations, such as TP53, PTEN, STK11, CHEK2, ATM, BRIP1, and PALB2 mutations. This review highlights translational research advances with regard to the development of probabilistic models for hereditary breast cancer syndromes, the identification of specific genetic mutations responsible for these syndromes, as well as their testing… CONTINUE READING
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    References

    SHOWING 1-10 OF 111 REFERENCES
    ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
    • 653
    BRCA1 and BRCA2: 1994 and beyond
    • 861
    • PDF
    Germline TP53 mutations and Li‐Fraumeni syndrome
    • 408
    The emerging landscape of breast cancer susceptibility
    • 464
    Tumors associated with p53 germline mutations: a synopsis of 91 families.
    • 423
    Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations
    • 728
    • PDF
    Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • 1,910
    P53 germline mutations in childhood cancers and cancer risk for carrier individuals
    • 342