Translational accuracy of aminoacyl-tRNA synthetases: implications for atherosclerosis.

  title={Translational accuracy of aminoacyl-tRNA synthetases: implications for atherosclerosis.},
  author={Hieronim Jakubowski},
  journal={The Journal of nutrition},
  volume={131 11},
Aminoacyl-tRNA synthetases establish the rules of the genetic code by matching amino acids (AA) with their cognate tRNA. When differences in binding energies of AA to an aminoacyl-tRNA synthetase are inadequate, editing is used as a major determinant of the enzyme selectivity. Metabolic conversion of the nonprotein AA homocysteine (Hcy) to the thioester Hcy thiolactone by methionyl-, isoleucyl-, and leucyl-tRNA synthetases in vivo shows that continuous editing of incorrect AA is part of the… CONTINUE READING
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