Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.

@article{Abraham2016TranslationalSO,
  title={Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.},
  author={Nader G Abraham and Joshua M Junge and George S. Drummond},
  journal={Trends in pharmacological sciences},
  year={2016},
  volume={37 1},
  pages={17-36}
}
The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic syndrome. This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease. The HO system engages with other systems to mitigate the deleterious effects of oxidative stress in obesity and cardiovascular disease (CVD). Recent reports indicate that HO-1/HO-2 protein expression and HO activity… CONTINUE READING