Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity

@article{Kelleher2004TranslationalRM,
  title={Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity},
  author={Raymond J. Jr. Kelleher and Arvind Govindarajan and Susumu Tonegawa},
  journal={Neuron},
  year={2004},
  volume={44},
  pages={59-73}
}
Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely focused on transcriptional regulation. However, a growing body of evidence now supports a crucial role for neuronal activity-dependent mRNA translation, which may occur in dendrites for a subset of neuronal mRNAs. Recent work has begun to… Expand
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