Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity

  title={Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity},
  author={R. J. Kelleher and A. Govindarajan and S. Tonegawa},
  • R. J. Kelleher, A. Govindarajan, S. Tonegawa
  • Published 2004
  • Medicine, Biology
  • Neuron
  • Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely focused on transcriptional regulation. However, a growing body of evidence now supports a crucial role for neuronal activity-dependent mRNA translation, which may occur in dendrites for a subset of neuronal mRNAs. Recent work has begun to… CONTINUE READING

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