Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.

@article{Kazdoba2016TranslationalMM,
  title={Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.},
  author={Tatiana M Kazdoba and Prescott T. Leach and Mu Yang and Jill L Silverman and Marjorie Solomon and Jacqueline N. Crawley},
  journal={Current topics in behavioral neurosciences},
  year={2016},
  volume={28},
  pages={
          1-52
        }
}
Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and more recently knockout rats, have been generated for many of the de novo single gene mutations and copy number variants (CNVs) detected in ASD and comorbid neurodevelopmental disorders. Mouse models incorporating genetic and environmental manipulations have been employed for preclinical… CONTINUE READING
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