Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors.

@article{Torikai2016TranslationalIF,
  title={Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors.},
  author={Hiroki Torikai and Laurence J. N. Cooper},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2016},
  volume={24 7},
  pages={1178-86}
}
Chimeric antigen receptor (CAR) endows specificity to T-cells independent of human leukocyte antigen (HLA). This enables one immunoreceptor to directly target the same surface antigen on different subsets of tumor cells from multiple HLA-disparate recipients. Most approaches manufacture individualized CAR(+)T-cells from the recipient or HLA-compatible donor, which are revealing promising clinical results. This is the impetus to broaden the number of patients eligible to benefit from adoptive… CONTINUE READING
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