Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.

Abstract

The intratumor microenvironment generates phenotypically distinct but interconvertible malignant cell subpopulations that fuel metastatic spread and therapeutic resistance. Whether different microenvironmental cues impose invasive or therapy-resistant phenotypes via a common mechanism is unknown. In melanoma, low expression of the lineage survival oncogene… (More)
DOI: 10.1101/gad.290940.116

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Cite this paper

@article{Falletta2017TranslationRI, title={Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.}, author={Paola Falletta and Lu{\'i}s S{\'a}nchez-del-Campo and Jagat Chauhan and Maike Effern and Amy S Kenyon and Christopher John Kershaw and Robert Siddaway and Richard J. Lisle and Rasmus Freter and Matthew J Daniels and Xin Lu and Thomas T{\"{u}ting and M. Middleton and Francesca Buffa and Anne E. Willis and Graham D Pavitt and Ze'ev A. Ronai and Tatjana Sauka-Spengler and Michael Hoelzel and C. R. Goding}, journal={Genes & development}, year={2017}, volume={31 1}, pages={18-33} }