Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

@article{Lu2004TranslationRA,
  title={Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response},
  author={Phoebe D. Lu and Heather P Harding and David Ron},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={167},
  pages={27 - 33}
}
Stress-induced eukaryotic translation initiation factor 2 (eIF2) alpha phosphorylation paradoxically increases translation of the metazoan activating transcription factor 4 (ATF4), activating the integrated stress response (ISR), a pro-survival gene expression program. Previous studies implicated the 5' end of the ATF4 mRNA, with its two conserved upstream ORFs (uORFs), in this translational regulation. Here, we report on mutation analysis of the ATF4 mRNA which revealed that scanning ribosomes… CONTINUE READING

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