Translation of the human c-myc P0 tricistronic mRNA involves two independent internal ribosome entry sites

@article{Nanbru2001TranslationOT,
  title={Translation of the human c-myc P0 tricistronic mRNA involves two independent internal ribosome entry sites},
  author={C{\'e}cile Nanbru and A. Darder Prats and Louis Droogmans and Patrick Defrance and Georges Huez and V{\'e}ronique Kruys},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={4270-4280}
}
The human c-myc proto-oncogene is transcribed from four alternative promoters (P0, P1, P2, and P3) giving rise to mRNAs having 5′ leader sequences of various length. The c-myc P0 mRNA contains three open reading frames (ORFs), the last one encoding c-Myc1 and c-Myc2 proteins generated by alternative translation initiated at CUG and AUG codons. The middle ORF (MYCHEX1) and the 5′ ORF (ORF1) code for proteins 188 and 114 amino acids in length, respectively. We and others previously identified an… CONTINUE READING

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