Translation of the genetic message: factors involved in the initiation of protein synthesis.

@article{Stanley1966TranslationOT,
  title={Translation of the genetic message: factors involved in the initiation of protein synthesis.},
  author={Wendell M. Stanley and Margarita Salas and A. J. Wahba and Severo Ochoa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1966},
  volume={56 1},
  pages={
          290-5
        }
}
  • W. M. Stanley, M. Salas, S. Ochoa
  • Published 1 July 1966
  • Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Aided by grants AM-01845, AM-08953, and FR-05399 from the National Institutes of Health, U.S. Public Health Service, and E. I. du Pont de Nemours and Co., Inc. 
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Initiation factor F2a of E. coli seems to recognize only fMet-tRNAf. This may be analogous to the recognition of other aminoacyl-tRNAs by elongation factor T.
Control of Translation by T4 Phage : Altered Ribosome Binding at R17 Initiation Sites
After infection of E. coli by T4 phage, ribosomes lose their ability to bind efficiently to the coat and synthetase initiation sites of R17 RNA. This change lies in the initiator factor fraction.
The involvement of RNA in protein synthesis.
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The binding of tRNA to ribosomes has been extensively studied with both bacterial and mammalian systems and there is a reaction between the 30S portion of the ribosome and the tRNA molecule.
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At least three factors, M1, M2 and M3, are required for initiating the synthesis of new and complete haemoglobin α and β chains at low Mg2+ concentration. The M factors are distinct from the chain…
Identification and Functional Characterization of the Protein controlled by the Streptomycin-resistant Locus in E. coli
The streptomycin locus of E. coli specifies a 30S ribosomal protein which determines the sensitivity of the 30S subunit to streptomycin and streptomycin induced errors of translation.
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In this article Dr Davis reviews recent developments in the search for the precise nature of the cycle of ribosomes in protein synthesis.
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