Translation of the F protein of hepatitis C virus is initiated at a non-AUG codon in a 11 reading frame relative to the polyprotein

Abstract

The hepatitis C virus (HCV) genome contains an internal ribosome entry site (IRES) followed by a large open reading frame coding for a polyprotein that is cleaved into 10 proteins. An additional HCV protein, the F protein, was recently suggested to result from a 11 frameshift by a minority of ribosomes that initiated translation at the HCV AUG initiator… (More)

Topics

9 Figures and Tables

Slides referencing similar topics