Translation of the F protein of hepatitis C virus is initiated at a non-AUG codon in a 11 reading frame relative to the polyprotein


The hepatitis C virus (HCV) genome contains an internal ribosome entry site (IRES) followed by a large open reading frame coding for a polyprotein that is cleaved into 10 proteins. An additional HCV protein, the F protein, was recently suggested to result from a 11 frameshift by a minority of ribosomes that initiated translation at the HCV AUG initiator… (More)


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