Translation of NRF mRNA is mediated by highly efficient internal ribosome entry.

  title={Translation of NRF mRNA is mediated by highly efficient internal ribosome entry.},
  author={Andr{\'e} Oumard and Michael Hennecke and Hansjoerg Hauser and Mahtab Nourbakhsh},
  journal={Molecular and cellular biology},
  volume={20 8},
The ubiquitous transcription factor NRF (NF-kappaB repressing factor) is a constitutive transcriptional silencer of the multifunctional cytokine interferon-beta. NRF mRNA contains a long 5' untranslated region (5'UTR) predicted to fold into a strong secondary structure. The presence of stable hairpins is known to be incompatible with efficient translation by ribosomal scanning. Using dicistronic reporter gene constructs, we show that the NRF 5'UTR acts as an internal ribosome entry site (IRES… CONTINUE READING
27 Citations
24 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 27 extracted citations


Publications referenced by this paper.
Showing 1-10 of 24 references

Cell cycle synchronization of porcin primary fibroblasts: effects of serum withdrawal and reversible cell cycle inhibitors

  • W. A. Kues, M. Anger, J. W. Carnwath, J. Motlik, H. Niemann, D. Paul
  • Theriogenology
  • 1999

Similar Papers

Loading similar papers…