Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.

  title={Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.},
  author={Sybille Krau\ss and Nadine Griesche and Ewa Jastrzębska and Changwei Chen and D{\'e}sir{\'e}e Rutschow and Clemens Achm{\"u}ller and Stephanie Dorn and Sylvia M. Boesch and Maciej Lalowski and Erich E. Wanker and Rainer Schneider and Susann Schweiger},
  journal={Nature communications},
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian… CONTINUE READING
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The PP2a-specific ubiquitin ligase Mid1 is a sequence-dependent regulator of translation efficiency controlling 3phosphoinositide dependent protein kinase-1 (PDPK-1)

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