Translation initiation in eukaryotes: Versatility of the scanning model

Abstract

It is generally accepted that the initiation of translation in eukaryotes involves the binding of the 40S ribosomal subunit to the capped 5′ end of an mRNA and subsequent scanning of 5′ UTR in search of an initiation codon. However, until recently this has remained a mere hypothesis. This review describes the novel experimental evidence in support of this… (More)
DOI: 10.1134/S0006297912130056

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