Translation initiation: variations in the mechanism can be anticipated

@article{Malys2010TranslationIV,
  title={Translation initiation: variations in the mechanism can be anticipated},
  author={Naglis Malys and John E. G. McCarthy},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={991-1003}
}
Translation initiation is a critical step in protein synthesis. Previously, two major mechanisms of initiation were considered as essential: prokaryotic, based on SD interaction; and eukaryotic, requiring cap structure and ribosomal scanning. Although discovered decades ago, cap-independent translation has recently been acknowledged as a widely spread mechanism in viruses, which may take place in some cellular mRNA translations. Moreover, it has become evident that translation can be initiated… Expand
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References

SHOWING 1-10 OF 142 REFERENCES
Was the initiation of translation in early eukaryotes IRES-driven?
TLDR
It is postulated that the first eukaryotic mRNAs were translated in a cap-independent, IRES-driven manner that was then superseded in evolution by the cap-dependent mechanism, rather than vice versa. Expand
Translation Initiation in Bacteria
This chapter summarizes the most important advances concerning structural and mechanistic aspects of translation initiation in bacteria which have occurred since the appearance of the last reviews onExpand
Dynamic evolution of translation initiation mechanisms in prokaryotes
TLDR
The findings indicate that, although translation initiation is indispensable for all protein-coding genes in the genome of every species, its mechanisms have dynamically changed during evolution. Expand
Initiation of translation in prokaryotes and eukaryotes.
TLDR
The binding of Met-tRNA to ribosomes is mediated by a GTP-binding protein in both prokaryotes and eukaryotes, but the more complex structure of the eukARYotic factor (eIF-2) and its association with other proteins underlie some aspects of initiation unique to eUKaryotes. Expand
Universally conserved translation initiation factors.
  • N. Kyrpides, C. Woese
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
It is demonstrated herein that the "analogous" translation initiation factors IF-1 and eIF-1A are actually related in sequence, and the "eukaryotic" translation factor SUI1 is universal in distribution, which implies that at the universal ancestor stage, a translation initiation mechanism either did not exist or was of a different nature than the extant processes. Expand
Structure-function insights into prokaryotic and eukaryotic translation initiation.
TLDR
First three-dimensional pictures of the particularly complex eukaryotic translation initiation machinery have been obtained, revealing how initiation factors tune the ribosome for recruiting the mRNA. Expand
Regulation of translation via mRNA structure in prokaryotes and eukaryotes.
TLDR
The scanning model provides a framework for understanding how small open reading frames near the 5' end of the mRNA can down-regulate translation and how this constraint is sometimes abrogated by changing the structure of the RNA, sometimes with clinical consequences. Expand
Leaderless mRNAs in bacteria: surprises in ribosomal recruitment and translational control
TLDR
The faithful translation of lead‐erless mRNAs in heterologous systems shows that the ability to translate leaderless m RNAs is an evo‐lutionarily conserved function of the translational apparatus. Expand
Selective stimulation of translation of leaderless mRNA by initiation factor 2: evolutionary implications for translation
TLDR
It is suggested that the start codon of leaderless mRNAs is recognized by a 30S–fMet‐tRNAfMet–IF2 complex, an intermediate equivalent to that obligatorily formed during translation initiation in eukaryotes. Expand
Begin at the beginning: evolution of translational initiation.
TLDR
Known features of the molecular machinery for initiation in the primary domains of life, Bacteria, Archaea and Eukarya, are reviewed and conserved features that may be useful for reconstructing a model of the ancestral initiation apparatus are identified. Expand
...
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2
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4
5
...