Translation elongation can control translation initiation on eukaryotic mRNAs.

  title={Translation elongation can control translation initiation on eukaryotic mRNAs.},
  author={Dominique F. Chu and Eleanna Kazana and No{\'e}mie Bellanger and T. Dineshor Singh and Mick F Tuite and Tobias von der Haar},
  journal={The EMBO journal},
  volume={33 1},
Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias. Although recent studies have shown strong effects of codon usage changes on protein expression levels and cellular physiology, no translational control mechanism is known that links codon usage to protein expression levels. Here, we demonstrate a novel translational control mechanism that… CONTINUE READING
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