Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation.

@article{Liepelt2014TranslationCO,
  title={Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation.},
  author={Anke Liepelt and Jana C. Mossanen and Ferdinand Geier and Felix Heymann and Rebecca De Santis and Frank Tacke and Gernot Marx and Dirk H. Ostareck and Antje Ostareck-Lederer},
  journal={RNA},
  year={2014},
  volume={20 6},
  pages={
          899-911
        }
}
Macrophage activation by bacterial lipopolysaccharides (LPS) is induced through Toll-like receptor 4 (TLR4). The synthesis and activity of TLR4 downstream signaling molecules modulates the expression of pro- and anti-inflammatory cytokines. To address the impact of post-transcriptional regulation on that process, we performed RIP-Chip analysis. Differential association of mRNAs with heterogeneous nuclear ribonucleoprotein K (hnRNP K), an mRNA-specific translational regulator in differentiating… CONTINUE READING
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