Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity

@inproceedings{Ivanov2017TranslationIF,
  title={Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity},
  author={Ivaylo P. Ivanov and Jiajie Wei and Stephen Z. Caster and Kristina Smith and Audrey M. Michel and Ying Zhang and Andrew E. Firth and Michael Freitag and Jay C. Dunlap and Deborah Bell-Pedersen and John F. Atkins and Matthew S. Sachs},
  booktitle={mBio},
  year={2017}
}
Neurospora crassa cpc-1 and Saccharomyces cerevisiae GCN4 are homologs specifying transcription activators that drive the transcriptional response to amino acid limitation. The cpc-1 mRNA contains two upstream open reading frames (uORFs) in its >700-nucleotide (nt) 5' leader, and its expression is controlled at the level of translation in response to amino acid starvation. We used N. crassa cell extracts and obtained data indicating that cpc-1 uORF1 and uORF2 are functionally analogous to GCN4… CONTINUE READING
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