Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin

@inproceedings{Losada2016TranslationEF,
  title={Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin},
  author={Alejandro Losada and Mar{\'i}a Jos{\'e} Mu{\~n}oz-Alonso and Carolina Garc{\'i}a and Pedro A. S{\'a}nchez-Murcia and Juan Fernando Mart{\'i}nez-Leal and Juan Manuel Dom{\'i}nguez and M Pilar Lillo and Federico Gago and Carlos M Galmarini},
  booktitle={Scientific reports},
  year={2016}
}
eEF1A2 is one of the isoforms of the alpha subunit of the eukaryotic Elongation Factor 1. It is overexpressed in human tumors and is endowed with oncogenic properties, favoring tumor cell proliferation while inhibiting apoptosis. We demonstrate that plitidepsin, an antitumor agent of marine origin that has successfully completed a phase-III clinical trial for multiple myeloma, exerts its antitumor activity by targeting eEF1A2. The drug interacts with eEF1A2 with a KD of 80 nM and a target… CONTINUE READING
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