Translation Elongation Factor 1A Facilitates the Assembly of the Tombusvirus Replicase and Stimulates Minus-Strand Synthesis

@inproceedings{Li2010TranslationEF,
  title={Translation Elongation Factor 1A Facilitates the Assembly of the Tombusvirus Replicase and Stimulates Minus-Strand Synthesis},
  author={Zhenghe Li and Judit Pogany and Steven Tupman and Anthony M. Esposito and Terri Goss Kinzy and Peter D Nagy},
  booktitle={PLoS pathogens},
  year={2010}
}
Replication of plus-strand RNA viruses depends on host factors that are recruited into viral replicase complexes. Previous studies showed that eukaryotic translation elongation factor (eEF1A) is one of the resident host proteins in the highly purified tombusvirus replicase complex. Using a random library of eEF1A mutants, we identified one mutant that decreased and three mutants that increased Tomato bushy stunt virus (TBSV) replication in a yeast model host. Additional in vitro assays with… CONTINUE READING
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