Translating the histone code into leukemia.

  title={Translating the histone code into leukemia.},
  author={Bryan E. Linggi and Stephen J. Brandt and Zu-Wen Sun and Scott W. Hiebert},
  journal={Journal of cellular biochemistry},
  volume={96 5},
The "histone code" is comprised of the covalent modifications of histone tails that function to regulate gene transcription. The post-translational modifications that occur in histones within the regulatory regions of genes include acetylation, methylation, phosphorylation, ubiquitination, sumoylation, and ADP-ribosylation. These modifications serve to alter chromatin structure and accessibility, and to act as docking sites for transcription factors or other histone modifying enzymes. Several… CONTINUE READING
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