Translating the genome in time and space: specialized ribosomes, RNA regulons, and RNA-binding proteins.

  title={Translating the genome in time and space: specialized ribosomes, RNA regulons, and RNA-binding proteins.},
  author={Zhen Shi and Maria Barna},
  journal={Annual review of cell and developmental biology},
  • Zhen Shi, M. Barna
  • Published 13 November 2015
  • Biology
  • Annual review of cell and developmental biology
A central question in cell and developmental biology is how the information encoded in the genome is differentially interpreted to generate a diverse array of cell types. A growing body of research on posttranscriptional gene regulation is revealing that both global protein synthesis rates and the translation of specific mRNAs are highly specialized in different cell types. How this exquisite translational regulation is achieved is the focus of this review. Two levels of regulation are… 

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