Translating the Histone Code

  title={Translating the Histone Code},
  author={T. Jenuwein and C. Allis},
  pages={1074 - 1080}
  • T. Jenuwein, C. Allis
  • Published 2001
  • Medicine, Biology
  • Science
  • Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate synergistic or antagonistic interaction affinities for chromatin-associated proteins, which in turn dictate dynamic transitions between transcriptionally active or transcriptionally silent chromatin… CONTINUE READING

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