Translating the Histone Code

@article{Jenuwein2001TranslatingTH,
  title={Translating the Histone Code},
  author={Thomas Jenuwein and C. David Allis},
  journal={Science},
  year={2001},
  volume={293},
  pages={1074 - 1080}
}
Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate synergistic or antagonistic interaction affinities for chromatin-associated proteins, which in turn dictate dynamic transitions between transcriptionally active or transcriptionally silent chromatin… 
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Findings that the structured globular domain of the nucleosome core particle plays a key role regulating chromatin dynamics are reviewed and calls for the re-examination of current models for the epigenetic regulation of chromatin structure.
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