Translating the Histone Code

@article{Jenuwein2001TranslatingTH,
  title={Translating the Histone Code},
  author={Thomas Jenuwein and C. David Allis},
  journal={Science},
  year={2001},
  volume={293},
  pages={1074 - 1080}
}
Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate synergistic or antagonistic interaction affinities for chromatin-associated proteins, which in turn dictate dynamic transitions between transcriptionally active or transcriptionally silent chromatin… Expand
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References

SHOWING 1-10 OF 92 REFERENCES
Review: chromatin structural features and targets that regulate transcription.
TLDR
The nucleosome and chromatin fiber provide the common structural framework for transcriptional control in eukaryotes and the roles of chromatin and chromosomal structural biology in human disease are illuminated. Expand
The language of covalent histone modifications
TLDR
It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events. Expand
Histone acetylation and an epigenetic code.
  • B. Turner
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2000
TLDR
Recent evidence raises the interesting possibility that an acetylation-based code may operate through both mitosis and meiosis, providing a possible mechanism for germ-line transmission of epigenetic changes. Expand
Histone deacetylases: complex transducers of nuclear signals.
Histone acetylation influences both gene transcription and chromatin assembly after DNA replication and the enzymes that regulate this property of chromatin are likely to play a key role inExpand
Histone methylation versus histone acetylation: new insights into epigenetic regulation.
TLDR
Taken together, these new findings suggest that histone methylation may provide a stable genomic imprint that may serve to regulate gene expression as well as other epigenetic phenomena. Expand
Re-SET-ting heterochromatin by histone methyltransferases.
TLDR
The recent discovery of the first histone Lys methyltransferase has allowed the identification of a molecular mechanism in which the specific methylation of histone H3 at Lys9 generates a binding site for heterochromatin-associated proteins. Expand
Esa1p Is an Essential Histone Acetyltransferase Required for Cell Cycle Progression
TLDR
Characterization of ESA1 is reported, an essential gene that is a member of the MYST family that includes two yeast silencing genes, human genes associated with leukemia and with the human immunodeficiency virus type 1 Tat protein, and Drosophila mof, a gene essential for male dosage compensation. Expand
Regulation of chromatin structure by site-specific histone H3 methyltransferases
TLDR
A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested. Expand
Epigenetic inheritance of active chromatin after removal of the main transactivator.
The Drosophila Polycomb and trithorax group proteins act through chromosomal elements such as Fab-7 to maintain repressed or active gene expression, respectively. A Fab-7 element is switched from aExpand
Role of protein methylation in chromatin remodeling and transcriptional regulation
TLDR
In future work, it will be important to develop methods for evaluating the precise roles of protein methylation in the regulation of native genes in physiological settings, e.g. by using chromatin immunoprecipitation assays, differentiating cell culture systems, and genetically altered cells and animals. Expand
...
1
2
3
4
5
...