Translating ribosomes inhibit poliovirus negative-strand RNA synthesis.

@article{Barton1999TranslatingRI,
  title={Translating ribosomes inhibit poliovirus negative-strand RNA synthesis.},
  author={David J. Barton and B Joan Morasco and James Bert Flanegan},
  journal={Journal of virology},
  year={1999},
  volume={73 12},
  pages={10104-12}
}
Poliovirus has a single-stranded RNA genome of positive polarity that serves two essential functions at the start of the viral replication cycle in infected cells. First, it is translated to synthesize viral proteins and, second, it is copied by the viral polymerase to synthesize negative-strand RNA. We investigated these two reactions by using HeLa S10 in vitro translation-RNA replication reactions. Preinitiation RNA replication complexes were isolated from these reactions and then used to… CONTINUE READING
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