Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond.

Abstract

The early development of novel nicotinic drugs for Tourette's and depression was a very long journey in discovery, which began with basic behavioral neuroscience studies aimed at understanding how cholinergic and dopaminergic systems interact in the basal ganglia to control goal directed movement. These early rodent studies with nicotine and dopamine… (More)
DOI: 10.1016/j.physbeh.2012.06.023

Topics

Cite this paper

@article{Sanberg2012TranslatingLD, title={Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond.}, author={Paul R. Sanberg and Cecilia Vindrola-Padros and R. Douglas Shytle}, journal={Physiology & behavior}, year={2012}, volume={107 5}, pages={801-8} }