Translating genomic research into clinical practice: promise and pitfalls.

@article{Sparano2013TranslatingGR,
  title={Translating genomic research into clinical practice: promise and pitfalls.},
  author={Joseph A Sparano and Harry Ostrer and Paraic A. Kenny},
  journal={American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting},
  year={2013},
  pages={
          15-23
        }
}
Breast cancer is a heterogeneous disease associated with variable clinical outcomes despite standard local therapy for the primary tumor and systemic adjuvant therapy to prevent distant recurrence. Management decisions are typically made using classical prognostic and predictive clinicopathologic factors, and more recently gene expression profiling assays are commonly used in practice. Recent advances in genomic sequencing-often referred to collectively as next-generation sequencing (NGS)-have… CONTINUE READING