Translating endoplasmic reticulum biology into the clinic: a role for ER-targeted natural products?

@article{Pereira2015TranslatingER,
  title={Translating endoplasmic reticulum biology into the clinic: a role for ER-targeted natural products?},
  author={David M Pereira and P. Valent{\~a}o and G. Correia-da-Silva and N. Teixeira and P. Andrade},
  journal={Natural product reports},
  year={2015},
  volume={32 5},
  pages={
          705-22
        }
}
ER stress has been identified as a hallmark, and sometimes trigger, of several pathologies, notably cancer, inflammation and neurodegenerative diseases like Alzheimer's and Parkinson's. Among the molecules described in literature known to affect ER function, the majority are natural products, suggesting that natural molecules may constitute a significant arsenal of chemical entities for modulating this cellular target. In this review, we will start by presenting the current knowledge of ER… Expand
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