Translating cancer research into targeted therapeutics

@article{Bono2010TranslatingCR,
  title={Translating cancer research into targeted therapeutics},
  author={Johann S. de Bono and Alan Ashworth},
  journal={Nature},
  year={2010},
  volume={467},
  pages={543-549}
}
The emphasis in cancer drug development has shifted from cytotoxic, non-specific chemotherapies to molecularly targeted, rationally designed drugs promising greater efficacy and less side effects. Nevertheless, despite some successes drug development remains painfully slow. Here, we highlight the issues involved and suggest ways in which this process can be improved and expedited. We envision an increasing shift to integrated cancer research and biomarker-driven adaptive and hypothesis testing… CONTINUE READING
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