Translating cancer research into targeted therapeutics

  title={Translating cancer research into targeted therapeutics},
  author={Johann S. de Bono and Alan Ashworth},
The emphasis in cancer drug development has shifted from cytotoxic, non-specific chemotherapies to molecularly targeted, rationally designed drugs promising greater efficacy and less side effects. Nevertheless, despite some successes drug development remains painfully slow. Here, we highlight the issues involved and suggest ways in which this process can be improved and expedited. We envision an increasing shift to integrated cancer research and biomarker-driven adaptive and hypothesis testing… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 131 extracted citations

Early Phase Clinical Trial Designs - State of Play and Adapting for the Future.

Clinical oncology (Royal College of Radiologists (Great Britain)) • 2017
View 8 Excerpts
Highly Influenced

Pathway-based subnetworks enable cross-disease biomarker discovery

Nature Communications • 2018
View 4 Excerpts
Highly Influenced

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33

The Journal of experimental medicine • 2012
View 1 Excerpt
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 71 references

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

G Bollag
Natureadvance online publication • 2010

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

Reid, M A.H.
Br. J. Cancer 102, • 2010

A perspective on challenges and issues in biomarker development and drug and biomarker codevelopment

Taube, E S.
J. Natl. Cancer Inst. 101, • 2009

A systems approach to analysis of molecular complexity in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2009

Characterization of ERG , AR and PTEN gene status in circulating tumor cells frompatientswithcastration - resistantprostatecancer

G. Attard
CancerRes . • 2009

Similar Papers

Loading similar papers…