Translating biomolecular recognition into nanomechanics.

@article{Fritz2000TranslatingBR,
  title={Translating biomolecular recognition into nanomechanics.},
  author={Juergen Fritz and Marko Klaus Baller and Hans Peter Lang and Hugo E. Rothuizen and P. Vettiger and Ernst Meyer and H.-J. G{\"u}ntherodt and Ch. Gerber and James K. Gimzewski},
  journal={Science},
  year={2000},
  volume={288 5464},
  pages={
          316-8
        }
}
We report the specific transduction, via surface stress changes, of DNA hybridization and receptor-ligand binding into a direct nanomechanical response of microfabricated cantilevers. Cantilevers in an array were functionalized with a selection of biomolecules. The differential deflection of the cantilevers was found to provide a true molecular recognition signal despite large nonspecific responses of individual cantilevers. Hybridization of complementary oligonucleotides shows that a single… 

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  • Biology, Engineering
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
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Membrane-based chemomechanical transducer for the detection of aptamer-protein binding

  • Jun-kyu ChoiJunghoon Lee
  • Engineering, Biology
    2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
  • 2015
Clear-cut detection of molecular binding using a membrane transducer fabricated with conventional MEMS technology is shown through the implementation of CMR that rejects physical effects such as pressure and temperature, leaving only specific chemical binding responsible for resulting signal.
...

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