Translating Trendelenburg; back to the future

  title={Translating Trendelenburg; back to the future},
  author={Wim J. E. P. Lammers and Anne Marijke Lammers-van den Berg and John F. B. Morrison and Georg A. Petroianu},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Paul Trendelenburg was born in 1884 into a family with a strong medical background (Starke 1998, 2004). His father, Friedrich Trendelenburg, a surgeon, is still remembered for introducing the signs for diagnosing venous insufficiencies in the legs and paralysis of the gluteal muscle. Paul himself studied medicine in Grenoble, Switzerland, and then in Leipzig, Germany. In 1908, he joined the Pharmacology Department (“Pharmakologisches Institut”) in Freiburg, Germany, to work on his dissertation… 
An anthology from Naunyn-Schmiedeberg’s archives of pharmacology
Otto Schaumann was, what seems to be today an endangered species, namely a “classical” experienced in vitro and in vivo pharmacologist, combining an excellent knowledge of systemic physiology, pathophysiology, and medicinal chemistry.
Translating the seminal findings of Carl Lüderitz: A description in English of his extraordinary studies of gastrointestinal motility accompanied by a historical view of peristalsis
Carl Lüderitz provided the first comprehensive description of peristalsis in vivo in his publication from 1889 before Bayliss and Starling described the peristaltic reflex in isolated intestinal
An anthology from Naunyn-Schmiedeberg’s Archives of Pharmacology
  • M. Michel
  • Medicine
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2006
The present issue of Naunyn-Schmiedeberg’s Archives of Pharmacology contains the first of a series of comments on important contributions to pharmacology published in it, highlighting a ground-breaking paper by Paul Trendelenburg (1917).
Opioid-induced esophageal dysfunction.
OIED is frequent in chronic opioid users undergoing manometry for esophageal symptoms, especially at higher doses or with stronger opioids, and appears to be due to impaired inhibitory signals in the esophagus.
High definition mapping of circular and longitudinal motility in the terminal ileum of the brushtail possum Trichosurus vulpecula with watery and viscous perfusates
Neither the frequencies nor the rates of progression of circular and longitudinal contractile events, nor the temporal coordination between these events, varied with the apparent viscosity of the perfusate or altered in a manner that could facilitate mixing.
Local Motility, Flow and Mixing in Tubular Segments of the Gut
The contractile activity within the various tubular segments of the gut is reviewed in the first two chapters which describe motility in intestinal segments of increasingly complex form and function with detailed descriptions of the contractile constituents of peristalsis, segmentation and pendular movements.
Opioid receptors in the gastrointestinal tract
  • P. Holzer
  • Biology, Medicine
    Regulatory Peptides
  • 2009
Characterization of flow and mixing regimes within the ileum of the brushtail possum using residence time distribution analysis with simultaneous spatio‐temporal mapping
Ileal segment volume and oscillatory flow during the period of RTD determination were derived from spatiotemporal maps, and indicated that a coarser mixing regime prevailed and that absorption of nutrients from viscous digesta would rely to a greater degree on molecular diffusion.
Opioid-Induced Foregut Dysfunction.
The impact of opioid use on the lower gastrointestinal tract is well described, but recent opioid crisis has caused increased awareness of the detrimental effects of these drugs on esophageal and
Pharmacology of Opioids and their Effects on Gastrointestinal Function
This work focuses on the physiology of endogenous opioids and their receptors with particular reference to their effects on gastrointestinal function, the pharmacology of opioid drugs, and molecular and genetic factors that drive the activity of these powerful agents.


Edith Bülbring, 27 December 1903 - 5 July 1990
Edith Bülbring was distinguished both as a pharmacologist and as a smooth-muscle physiologist, and will undoubtedly be remembered as the world’s most influential scientist in this field.
A new hypothesis is postulated to explain how the strength as well as the direction of the waves of the small intestine can be regulated.
The movements and innervation of the small intestine
The wall of the rabbit's intestine was at the same time too delicate and too excitable to give any reliable results with the enterograph, so that all tracings were obtained by the insertion of a rubber balloon in the lumen of the gut.
A quantitative approach to recording peristaltic activity from segments of rat small intestine in vivo
Methods that allow correlation of propulsive reflexes of the intestine with measurements of intraluminal pressure, fluid movement and spatio‐temporal maps of intestinal wall movements for the first time in vivo are developed.
Quantitative analysis of peristalsis in the guinea‐pig small intestine using spatio‐temporal maps
Peristalsis was evoked in guinea‐pig small intestine by slow fluid infusion and spatio‐temporal maps of diameter and longitudinal movement were constructed and parameters of motion were calculated.
In vitro analysis of rat intestinal wall movements at rest and during propagated contraction: a new method.
Analysis of a propagate wave after cholinergic stimulation showed that it is characterized by an increase of the diameter of the intestine followed by a decrease, which allows analysis of the initiation of a propagated wave.
The peristaltic reflex: An analysis of the nerve pathways and their pharmacology
It is postulated that three factors may contribute to propulsion in the guinea-pig distal colon: ascending excitatory reflexes which evoke contractions above a bolus; descending inhibitory Reflexes which cause relaxations below; and contractions which, once set up in the circular muscle, travel in an anal direction.
Initiation of peristalsis by circumferential stretch of flat sheets of guinea‐pig ileum
Segments of isolated guinea‐pig intestine were distended slowly by intraluminal fluid infusion or by mechanical stretch as either a tube or flat sheet, and peristalsis was initiated by a discrete large excitatory junction potential which evoked bursts of smooth muscle action potentials.
Does the guinea‐pig ileum obey the ‘law of the intestine’?
It is suggested that the guinea‐pig ileum does not conform to the ‘law of the intestine’ as postulated by Bayliss & Starling (1899) .