Translating Dosage Compensation to Trisomy 21

@article{Jiang2013TranslatingDC,
  title={Translating Dosage Compensation to Trisomy 21},
  author={Jun Jiang and Yuanchun Jing and Gregory J Cost and Jen-Chieh Chiang and Heather J. Kolpa and Allison M. Cotton and Dawn M. Carone and Benjamin R. Carone and David A. Shivak and Dmitry Guschin and Jocelynn R Pearl and Edward J Rebar and Meg Byron and Philip D. Gregory and Carolyn J. Brown and Fyodor D. Urnov and Lisa L. Hall and Jeanne B. Lawrence},
  journal={Nature},
  year={2013},
  volume={500},
  pages={296 - 300}
}
Down’s syndrome is a common disorder with enormous medical and social costs, caused by trisomy for chromosome 21. We tested the concept that gene imbalance across an extra chromosome can be de facto corrected by manipulating a single gene, XIST (the X-inactivation gene). Using genome editing with zinc finger nucleases, we inserted a large, inducible XIST transgene into the DYRK1A locus on chromosome 21, in Down’s syndrome pluripotent stem cells. The XIST non-coding RNA coats chromosome 21 and… 
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