Translating 5‐HT4 receptor pharmacology

@article{Sanger2009Translating5R,
  title={Translating 5‐HT4 receptor pharmacology},
  author={Gareth John Sanger},
  journal={Neurogastroenterology \& Motility},
  year={2009},
  volume={21}
}
  • G. Sanger
  • Published 1 December 2009
  • Biology
  • Neurogastroenterology & Motility
Abstract  Since metoclopramide was first described (in 1964) there have been several attempts to develop compounds which retained gastrointestinal prokinetic activity (via 5‐HT4 receptor activation) but without the limiting side effects associated with dopamine D2 receptor antagonism. Early compounds (mosapride, cisapride, renzapride, tegaserod) were identified before several of the 5‐HT receptors were even described (including 5‐HT4 and 5‐HT2B), whereas prucalopride came later. Several… 

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