Transkinetoplastidy--a novel phenomenon involving bulk alterations of mitochondrion-kinetoplast DNA of a trypanosomatid protozoan.

@article{Lee1992TranskinetoplastidyaNP,
  title={Transkinetoplastidy--a novel phenomenon involving bulk alterations of mitochondrion-kinetoplast DNA of a trypanosomatid protozoan.},
  author={Seon Yeong Lee and Seong tae Lee and Kwang Poo Chang},
  journal={The Journal of protozoology},
  year={1992},
  volume={39 1},
  pages={190-6}
}
Dramatic and consistent changes of mitochondria or kinetoplast DNA (kDNA) were observed in certain variants of Leishmania amazonensis (A variants) selected in vitro for arsenite-resistance. This was found initially by comparing different lots of wild-type cells and their respective A variants resistant to 30 microM arsenite. The kDNAs isolated from these two groups had different restriction patterns and hybridized poorly to each other, whereas those from different lots within each of the two… CONTINUE READING