OBJECTIVE The purpose of our study was to evaluate the safety and efficacy of transjugular intrahepatic portosystemic shunts (TIPS) in pediatric and adult liver transplant recipients. A retrospective review of six TIPS placed in six liver transplant recipients-a pediatric patient with a split liver transplant, a pediatric patient with left lateral segment transplant, and four adult patients-was performed. CONCLUSION TIPS placement in both pediatric and adult liver transplant recipients is feasible. In liver transplant patients who are recipients of a left lateral segment or a split liver transplant, knowledge of the liver transplant anatomy is critical in the placement of TIPS. TIPS placement is a treatment option and a bridge to retransplantation for patients who have undergone liver transplantation and develop sequelae of portal hypertension.