Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence

@article{Shoval2014TransitionsIT,
  title={Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence},
  author={Gal Shoval and Ossnat Bar-Shira and Gil Zalsman and J. John Mann and Gal Chechik},
  journal={European Neuropsychopharmacology},
  year={2014},
  volume={24},
  pages={1123-1132}
}

Figures and Tables from this paper

The development of monoaminergic neurotransmitter systems in childhood and adolescence

  • M. Pitzer
  • Psychology, Medicine
    International Journal of Developmental Neuroscience
  • 2019

Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders

TLDR
Altering in the mRNA expression patterns of the HTR1E, OPRL1, O PRM1, TACR1, PRKG1, SCN9A and DRD4 genes provide further evidence for a relevant effect of the respective candidate genes on the pathophysiology of ASD.

Loss of Basal Forebrain Cholinergic Neurons Following Adolescent Binge Ethanol Exposure: Recovery With the Cholinesterase Inhibitor Galantamine

TLDR
The finding of no AIE-induced changes in total basal forebrain NeuN + neurons with galantamine reversal of AIe-induced ChAT + neuron loss, TLR4/RAGE-pNF-κB p65 signals, and epigenetic transcription silencing markers suggests that AIE does not cause cell death, but rather the loss of the cholinergic phenotype.

Wiring of higher-order cortical areas: Spatiotemporal development of cortical hierarchy.

SLC6A3 Is Associated With Relational Aggression in Children

TLDR
This work invited the parents of 327 children to complete a modified version of the MacArthur Health and Behavior Questionnaire (HBQ-P), which has a subscale for relational aggression and used logistic regression models that predicted relational aggression after controlling for covariates.

ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes

TLDR
It is found that in 5-HTTLPR Sallele homozygotes, ADHD symptoms in middle adolescence predicted exposure to the number of person-related life stressors later in adolescence (T2-T3, p = 0.001).

Genetic Correlates of Spirituality/Religion and Depression: A Study in Offspring and Grandchildren at High and Low Familial Risk for Depression

TLDR
The shared association of DRD2 by S/R and depression, generally found to be inversely related, calls for further research on their common physiological pathways, and the phenotypic expression of these pathways based upon use and environment.

Gene-environment interactions on the course of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms: From early into late adolescence

Hoewel het duidelijk is dat genen, omgeving en diens interacties oorzaken zijn van ADHD, is het ook belangrijk om te kijken of genen, omgevingsfactoren en gen-omgeving interacties onderscheid kunnen

Prefrontal dopaminergic mechanisms of adolescent cue extinction learning

..................................................................................................................................... i Declaration

References

SHOWING 1-10 OF 53 REFERENCES

Serotonin Receptor Expression in Human Prefrontal Cortex: Balancing Excitation and Inhibition across Postnatal Development

TLDR
A collective look at key serotonin receptors in human prefrontal cortex in terms of their likely neurophysiological effects and major cellular localization leads to a model that suggests developmental changes in expression of these individual HTRs may not perturb an overall balance between inhibitory and excitatory effects.

Ontogeny and regulation of the serotonin transporter: providing insights into human disorders.

Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

TLDR
Functional profiling revealed peak expression in late adolescence for genes associated with energy metabolism and protein and lipid synthesis, together with decreases for genes involved in glutamate and neuropeptide signalling and neuronal development/plasticity.

Spatiotemporal transcriptome of the human brain

TLDR
The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time.

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

TLDR
Findings show that postnatal developmental processes help to establish adult anxiety-like behaviour, and the normal role of the serotonin1A receptor during development may be different from its function when this receptor is activated by therapeutic intervention in adulthood.

HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory

TLDR
The possible reasons for the contrast between the prime relevance of HTR1B in regulating memory and motivation and the limited evidence brought by genetic association studies in humans are discussed, and some suggestions for possible future directions are provided.

Maturation of the adolescent brain

TLDR
Several factors, including age, sex, disease, nutritional status, and substance abuse have a significant impact on the maturation of the adolescent brain, and the influence of these clinically significant and socially important aspects are highlighted.

Frontal lobe and cognitive development

  • J. Fuster
  • Biology, Psychology
    Journal of neurocytology
  • 2002
In phylogeny as in ontogeny, the association cortex of the frontal lobe, also known as the prefrontal cortex, is a late-developing region of the neocortex. It is also one of the cortical regions to

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.

TLDR
Surprisingly, many gene expression changes previously attributed to aging, such as down-regulation of neural genes, initiate in early childhood, suggesting a direct link between developmental regulation and expression changes taking place in aging.

Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats

...