Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence

@article{Shoval2014TransitionsIT,
  title={Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence},
  author={G. Shoval and Ossnat Bar-Shira and G. Zalsman and J. Mann and Gal Chechik},
  journal={European Neuropsychopharmacology},
  year={2014},
  volume={24},
  pages={1123-1132}
}
Adolescence is a period of profound neurophysiological, behavioral, cognitive and psychological changes, but not much is known about the underlying molecular neural mechanisms. The aim of this study was to systematically analyze expression levels of the genes forming serotonergic and dopaminergic synapses during adolescence. We analyzed the mRNA expression profiles of genes that code for all components of serotonergic and dopaminergic synapses, in 16 brain areas from human and non-human… Expand
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References

SHOWING 1-10 OF 53 REFERENCES
Serotonin Receptor Expression in Human Prefrontal Cortex: Balancing Excitation and Inhibition across Postnatal Development
TLDR
A collective look at key serotonin receptors in human prefrontal cortex in terms of their likely neurophysiological effects and major cellular localization leads to a model that suggests developmental changes in expression of these individual HTRs may not perturb an overall balance between inhibitory and excitatory effects. Expand
Ontogeny and regulation of the serotonin transporter: providing insights into human disorders.
TLDR
This review synthesizes existing information on the ontogeny of SERT during embryonic and early postnatal development though adolescence, along with factors that influence its expression and function during these critical developmental windows to emphasize how inappropriate SERT expression or its dysregulation may be linked to the pathophysiology of psychiatric, cardiovascular and gastrointestinal diseases. Expand
Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia
TLDR
Functional profiling revealed peak expression in late adolescence for genes associated with energy metabolism and protein and lipid synthesis, together with decreases for genes involved in glutamate and neuropeptide signalling and neuronal development/plasticity. Expand
Spatiotemporal transcriptome of the human brain
TLDR
The generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains, finds that 86 per cent of the genes analysed were expressed, and that 90 per cent were differentially regulated at the whole-transcript or exon level acrossbrain regions and/or time. Expand
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
TLDR
Findings show that postnatal developmental processes help to establish adult anxiety-like behaviour, and the normal role of the serotonin1A receptor during development may be different from its function when this receptor is activated by therapeutic intervention in adulthood. Expand
HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory
TLDR
The possible reasons for the contrast between the prime relevance of HTR1B in regulating memory and motivation and the limited evidence brought by genetic association studies in humans are discussed, and some suggestions for possible future directions are provided. Expand
Maturation of the adolescent brain
TLDR
Several factors, including age, sex, disease, nutritional status, and substance abuse have a significant impact on the maturation of the adolescent brain, and the influence of these clinically significant and socially important aspects are highlighted. Expand
Frontal lobe and cognitive development
  • J. Fuster
  • Psychology, Medicine
  • Journal of neurocytology
  • 2002
In phylogeny as in ontogeny, the association cortex of the frontal lobe, also known as the prefrontal cortex, is a late-developing region of the neocortex. It is also one of the cortical regions toExpand
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.
TLDR
Surprisingly, many gene expression changes previously attributed to aging, such as down-regulation of neural genes, initiate in early childhood, suggesting a direct link between developmental regulation and expression changes taking place in aging. Expand
Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats
TLDR
A clear positive correlation was found between the individual level of trait-like aggressiveness and CSF concentrations of 5-HT, 5-HIAA, norepinephrine (NE), dopamine (DA), and 3,4-dihydroxyphenylacetic acid (DOPAC) in male Wildtype Groningen rats. Expand
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4
5
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