Transitions between closed and open conformations of TolC: the effects of ions in simulations.


Bacteria, such as Escherichia coli, use multidrug efflux pumps to export toxic substrates through their cell membranes. Upon formation of an efflux pump, the aperture of its outer membrane protein TolC opens and thereby enables the extrusion of substrate molecules. The specialty of TolC is its ability to dock to different transporters, making it a highly… (More)
DOI: 10.1016/j.bpj.2009.01.021