Transitions and transversions in evolutionary descent: An approach to understanding

  title={Transitions and transversions in evolutionary descent: An approach to understanding},
  author={Richard Holmquist},
  journal={Journal of Molecular Evolution},
In this paper I lay a quantitative theoretical groundwork for understanding the proportions of the possible types of base substitutions observed between 12 genes sharing a common ancestor and isolated from extant species. The experimentally observed types of base substitution between two sequenced genes do not give a direct measure of the types of base substitutions that occur during evolutionary descent. However, by use of a statistical assemblage of these observations, we can recover, without… CONTINUE READING
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