Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells

@inproceedings{Vieillard2016TransitionZA,
  title={Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells},
  author={Jennifer Vieillard and Marie Paschaki and Jean-Luc Duteyrat and C{\'e}line Augi{\`e}re and Elisabeth Cortier and Jean-Andr{\'e} Lapart and Jo{\"e}lle Thomas and B{\'e}n{\'e}dicte Durand},
  booktitle={The Journal of cell biology},
  year={2016}
}
The ciliary transition zone (TZ) is a complex structure found at the cilia base. Defects in TZ assembly are associated with human ciliopathies. In most eukaryotes, three protein complexes (CEP290, NPHP, and MKS) cooperate to build the TZ. We show that in Drosophila melanogaster, mild TZ defects are observed in the absence of MKS components. In contrast, Cby and Azi1 cooperate to build the TZ by acting upstream of Cep290 and MKS components. Without Cby and Azi1, centrioles fail to form the TZ… CONTINUE READING
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