Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals.

@article{Allen2012TransitionTP,
  title={Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals.},
  author={Paul Allen and Judy Luigjes and Oliver D. Howes and Alice Egerton and Kazuyuki Hirao and Isabel Valli and Joseph Kambeitz and Paolo Fusar-Poli and Matthew Broome and Philip K. McGuire},
  journal={Schizophrenia bulletin},
  year={2012},
  volume={38 6},
  pages={1268-76}
}
BACKGROUND People at ultra high risk (UHR) of psychosis have an elevated risk of developing a psychotic disorder, but it is difficult to predict which individuals will make a transition to frank illness. We investigated whether functional magnetic resonance imaging (fMRI) in conjunction with a phonological fluency task at presentation could distinguish subjects who subsequently developed psychosis from those who did not. METHODS Sixty-five subjects (41 with an UHR and 24 healthy controls… CONTINUE READING
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