Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

@article{Kasanetz2010TransitionTA,
  title={Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity},
  author={Fernando Kasanetz and V{\'e}ronique Deroche-Gamonet and Nad{\`e}ge Berson and {\'E}ric Balado and Mathieu Lafourcade and Olivier J.J. Manzoni and Pier Vincenzo Piazza},
  journal={Science},
  year={2010},
  volume={328},
  pages={1709 - 1712}
}
Addicts Lose Plasticity What are the biological mechanisms associated with the transition from occasional drug use to addiction? In rats, like in humans, even after a prolonged period of drug intake, only a limited number of animals develop addiction-like behavior despite the amount of drug taken by all subjects being the same. Kasanetz et al. (p. 1709) compared the expression of N-methyl-d-aspartate (NMDA)–dependent long-term depression (NMDA-LTD) in the nucleus accumbens of addicted and… 

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