Transition probability in cell proliferation, stochasticity in cell differentiation, and the restriction point of the cell cycle in one package.

@article{Golubev2012TransitionPI,
  title={Transition probability in cell proliferation, stochasticity in cell differentiation, and the restriction point of the cell cycle in one package.},
  author={Alexey Golubev},
  journal={Progress in biophysics and molecular biology},
  year={2012},
  volume={110 1},
  pages={87-96}
}
Clonal cells are known to display stochastically varying interdivision times (IMT) and stochastic choices of cell fates. These features are suggested in the present paper to stem from discrete transitions of genes between different modes of their engagement in transcription. These transitions are explained by stochastic events of assembly/disassembly of huge ensembles of transcription factors needed to built-up gene-specific transcription preinitiation complexes (PIC). The time required to… CONTINUE READING
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