Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO.


Benzimidazoles are prepared by intramolecular N-arylations of amidines mediated by potassium hydroxide in DMSO at 120 °C. In this manner, diversely substituted products have been obtained in moderate to very good yields.

DOI: 10.1021/ol403414v

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@article{Baars2014TransitionmetalfreeSO, title={Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO.}, author={Hannah Baars and Astrid Beyer and Stefanie V Kohlhepp and Carsten Bolm}, journal={Organic letters}, year={2014}, volume={16 2}, pages={536-9} }